“Thuggish Ruggish Bone” is the debut single of the rap group Bone Thugs-n-Harmony, from their debut EP Creepin on ah Come Up. It features local Cleveland singer Shatasha Williams. The song reached #22 on the Billboard Hot 100. The song was included in the soundtrack of the video game True Crime: Streets of LA; and the second half of Layzie Bone’s verse was reused on the track “Family Scriptures” on the Mo Thugs Family debut album, Family Scriptures.
The music video was shot near the Cuyahoga River on Cleveland’s westside, near from the Lakeview Estates public housing units. The music video also featured rapper Eazy-E.